You've got some real interesting posts in a couple of threads here. You sure you're not a Packers fan???
You might be right on Atlanta. I can hope. The Lions' weakness is against the run up the middle. A couple of different backs have demonstrated that. It's the natural downfall of the "wide 9". The Colts over NE would be the upset of the year, but if you go with that one, don't put too much money on it. I'd like to think you won't be broke for Christmas.
Have yet to make up my mind officially on the game. I think Atlanta has some good matchups in this game though. Hard to see the Lions maybe dropping two in a row at home but they are hardly unbeatble. The Falcons can run on them and stop the run decently themselves. Matt Ryan is also pretty decent indoors.
I am ticked off the Cowboys lost the Pats game. The game was there for them to take IMO and it's on their offense.
As for the Colts, I have yet to pick us to win a game this year. Just never liked the matchups. Week 1, thats tough even with Peyton on the road in Houston. They creamed us last year week 1. Week 2, even with Peyton we have historically struggled with the Browns. That is one trend I have stuck with all these years. Week 3, we matchup well with the Steelers this year. Our defensive speed and especially at DE was going to give them trouble. Week 4, Bucs....well this one I was torn on. I thought we might have gotten beaten by more. I was not impressed by the Bucs. Then we had the Chiefs. With Manning last year we struggled to beat them at home. We just got through with Cincy, did not like the matchup. Thats an underrated D. Cincy is pretty underrated.
The team made a huge mistake going with Collins. Not sure what the deal there was. He is a horrible fit for our offense and takes too long to release the ball. With Painter possibly starting the first two games he might have been warmed up more and ready and we possibly beat Steelers/Bucs.
This weekend in NO we are 14 point underdogs. Yes I know Brees is great but that might be a bit high depending on how the Saints D plays. It's indoors and our D will be fast. Problem is we are missing possibly a few more key players like Addai and a few on both lines. I do think we might be able to exploit the Saints D though. They are coming off a loss though sadly, but to the Bucs? Thats a big alarm for me with the Saints.
Not sure who I like as a true upset this week yet. Falcons over Lions seems like the sexiest so far and most realistic. If my Colts upset a quality team it won't be predicted ahead of time. The odds will increase though with every game that eventually we will win a few. I would be beyond shocked if we finished 0-16.
Interesting the Colts play several SB/playoff hopeful contenders this season; Pats/Saints/Ravens/Falcons/Titans/Texans. I get a good sense of who I think is for real or who isn't after we play them.

The pressure is on everyone not to lose to the Manning less Colts. It's embarrassing to do so it seems.
No don't worry, I won't be losing money. I am not silly enough to bet a lot on a team like the Colts this year. I don't really bet much money anyway unless it's a big game (usually playoffs) and I feel strongly about a team.