I was in a league last year that gave one passing yard the same amount of points as one rushing yard, which made it a very QB-friendly game. For example - I would get more points from a QB who threw 200 yards than a RB who ran for 199 yards. Seems quite unfair. In those leagues, you should, of course, pick 2 good QBs ASAP (I won last year because I picked Culpepper and McNabb). But these leagues are quite rare. Most leagues have RBs as the most consistent point grabbers - so if that's the case you HAVE TO draft RBs in the first and usually second round. Find a RB that you know will be the starter, and you should be ok. There will be plenty of good QBs by the time you hit the third round, and more than enough WRs in the later rounds. Do not pick a defense or kicker early. Just because you see one guy picking one early, do not fall into their trap and follow them. RBs are always good to have in excess.