I propose a compromise. In base/3-4/okie/whatever you want to call it, go corner-okie (pretty sure they did this in 2009?). Secondary would be Shields, Woodson, Burnett, and Williams. When they go Nickel, bring Peprah off the bench at safety, kick Woodson down to the nickel back.
Also possible, though risky, that they stay in corner-okie when offensive substitutions would normally demand nickel. You'd have 3 cover guys and a single high safety.
The trickier part, in my mind, in that setup would be getting the best/most worthy pass rushing/defending front 7. I just don't see enough of them healthy on the roster right now. It would be interesting to cobble together a 2-5 of Raji, Neal, Matthews, Zombo, So'oto, Walden, and Whoever-Our-Best-Cover-LB-Is, but who would that be? And 3 of those are currently nicked up.